Hemp seed oil can offer several potential benefits for domestic guinea pigs, mice, and rats when used in moderation and as part of a well-balanced diet. It's important to note that while hemp seed oil contains various nutrients, it should not be the sole source of nutrition for these animals. Here are some potential benefits:

1. Essential Fatty Acids: Hemp seed oil is rich in omega-3 and omega-6 fatty acids, which are essential for the overall health of rodents. These fatty acids play a crucial role in maintaining healthy skin and fur, as well as supporting the functioning of the nervous system.

2. Joint Health: The anti-inflammatory properties of omega-3 fatty acids in hemp seed oil may help support joint health in rodents, preventing issues like arthritis.

3. Skin and Coat Health: The fatty acids in hemp seed oil contribute to a shiny and healthy coat. This can be particularly beneficial for long-haired rodents such as guinea pigs.

4. Immune System Support: Hemp seed oil contains various antioxidants, which can help support the immune system and protect against oxidative stress.

5. Cardiovascular Health: The omega-3 fatty acids in hemp seed oil may contribute to cardiovascular health by promoting proper blood circulation and reducing inflammation.

6. Brain Function: Essential fatty acids are important for the development and maintenance of the nervous system, potentially supporting cognitive function in rodents.

7. Weight Management: Hemp seed oil is calorie-dense, so it can be a good source of additional calories for underweight rodents or those requiring extra energy.

When introducing hemp seed oil into the diet of guinea pigs, mice, or rats, it's crucial to do so gradually and in small amounts. It's also essential to consult with a veterinarian who can provide guidance on the appropriate quantity for your specific pets and monitor their overall health and well-being. Additionally, always choose high-quality, cold-pressed hemp seed oil to ensure that the beneficial nutrients are preserved.